The Research wing of TMCHRC was initiated and activated by the guidelines of the then Advisor Dr. Banzal in the year 2011 and headed by Dr. P. Thirumalaikolundu Subramanian. This wing was named as Central Research Lab (CRL). Later it was named as Health Science Research comprising of a committee and the infrastructure was named as Research Cell and now designated as Institutional Research Board (IRB) as per the aspiration of Dr. Sukumaran Annamalai, the Dean. The IRB is now having three faculty members exclusively for research and development. The IRB is governed by a statutory body designated by the Chairperson (The Dean) and comprised of 17 members including the Staff of the IRB and equipped with basic infrastructure facilities including instrumentation to proceed on basic research. The IRB of TMCHRC has been promoting research activities in Medical and paramedical sciences and collaborating with various national institutes. The vision of IRB is to develop these research facilities into a nationally recognized center to promote and carry out research activities in health science and to be a referral center for communicable, non-communicable diseases, emerging and re-emerging infectious diseases.